Gastrointestinal Pharmacology Interest Group (GPIG)

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Objective

This group aims to organize research teams to work on novel pharmacologic aspects of gastrointestinal diseases and drugs. This group can contribute to making proposals for original projects or review papers in this interesting field.

Definition

Gastrointestinal Pharmacology is the field of investigating pharmacological effects and mechanisms of action of drugs or natural drugs on the gastrointestinal system.

Group members

Founder

Amir Hossein Abdolghaffari

Managing Director

Zahra Najafi Arab

Member

Paper

A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine

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A review on symptoms, treatments protocols, and proteomic profile in sulfur mustard-exposed victims.

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Role of Toll-Like Receptors in Inflammatory Bowel Disease

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Immunomodulatory and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease (IBD): - Turning Strong Rationale into Strong Evidence?

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Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets.

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Effects of alpha lipoic acid and its derivative "andrographolid-lipoic acid-1" on ulcerative colitis: A systematic review with meta-analysis of animal studies.

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The Protective Effect of Melissa officinalis L. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway.

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An update on dietary consideration in inflammatory bowel disease: anthocyanins and more.

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Neuroprotective Agents in the Intensive Care Unit: -Neuroprotective Agents in ICU.

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Neuroprotective effects of antioxidants in the management of neurodegenerative disorders: A literature review.

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Beneficial Effects of Trachyspermum ammi (L.) Sprague on Rat Irritable Bowel Syndrome

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Natural flavonoids for the prevention of colon cancer: A comprehensive review of preclinical and clinical studies.

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Natural polyphenols for the prevention of irritable bowel syndrome: molecular mechanisms and targets; a comprehensive review.

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Polyphenols targeting diabetes via the AMP-activated protein kinase pathway; future approach to drug discovery.

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Targeting ubiquitin-proteasome pathway by natural products: Novel therapeutic strategy for treatment of neurodegenerative diseases

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Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease

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Targeting mammalian target of rapamycin: prospects for the treatment of inflammatory bowel diseases

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Wound healing activity of the flowers of Lilium candidum L. in burn wound model in rats

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Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways

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PPARγ: A turning point for irritable bowel syndrome treatment

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Antibiotics with therapeutic effects on spinal cord injury: a review

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Current overview of opioids in progression of inflammatory bowel disease; pharmacological and clinical considerations

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Cinnamaldehyde targets TLR-4 and inflammatory mediators in acetic-acid induced ulcerative colitis model.

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Protective Effect of a Formulation Containing Pistacia atlantica Oleo-Gum-Resin and Honey on Experimental Model of Acetic Acid-Induced Colitis in Rats

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A narrative review of herbal preparations against RNA viruses

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Prospects of Saffron and its Derivatives in Alzheimer's Disease.

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Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention

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Ginger: A complementary approach for management of cardiovascular diseases

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Licofelone, a potent COX/5-LOX inhibitor and a novel option for treatment of neurological disorders

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The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease

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Transmembrane serine protease 2 and angiotensin-converting enzyme 2 anti-inflammatory receptors for COVID-19/inflammatory bowel diseases treatment

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Ginger and its constituents: Role in treatment of inflammatory bowel disease

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Mammalian target of rapamycin; novel insight for management of inflammatory bowel diseases

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Ameliorative effects of standardized extract of Tamarix stricta Boiss. on acetic acid-induced colitis via modulating nitrergic pathways

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Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases

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Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases

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Licofelone attenuates the acetic acid-induced colitis in rats through suppression of the inflammatory mediators

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The Hydro-alcoholic Extract of Achillea wilhelmsii C. Koch Ameliorates Acetic Acid-induced Ulcerative Colitis through TLR-4

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Protective effects of curcumin against traumatic brain injury

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Regulatory Mechanisms of Vanillic acid in Cardiovascular Diseases: A Review.

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Budesonide-Loaded Hyaluronic Acid Nanoparticles for Targeted Delivery to the Inflamed Intestinal Mucosa in a Rodent Model of Colitis

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Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases

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IDO/Kynurenine; novel insight for treatment of inflammatory diseases

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Management of Hemorrhagic Fever Viruses: Intervention of Natural and Synthetic Products.

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Spinal Muscular Atrophy Treatment: The MTOR Regulatory Intervention

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Biodegradation of pharmaceutical compounds in industrial wastewater using biological treatment: a comprehensive overview

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Superoxide dismutase: a key target for the neuroprotective effects of curcumin

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Regulatory Mechanisms of Vanillic Acid in Cardiovascular Diseases: A Review

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Sodium Glucose Transporter-2 Inhibitors (SGLT2Is)-TLRs Axis Modulates Diabetes

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Impact of curcumin on p38 MAPK: therapeutic implications

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Therapeutic Potentials and Candidates for COVID-19

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Book

Dietary Fiber and Aging

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Aging and Cancer Prognosis

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Hepatobiliary Tumors: Immunopathology and Immunotherapy

Liver neoplasms are a kind of digestive cancers, by which hepatocellular carcinoma is one of the main pathological types of liver cancer that are associated with chronic viral hepatitis and cirrhosis. Conventional treatments such as chemotherapy and radiotherapy are not efficient enough to eliminate residual cancer cells. In recent years, tumor immunotherapy has emerged as a perfect method, in terms of delaying the progression of advanced tumors and protecting postoperative patients against tumor relapse and metastasis, besides its noteworthy safety and efficacy. Immune induction in tumor microenvironments such as adoptive cell therapy, cancer vaccination, immune checkpoint inhibitors, and oncolytic viruses is one of the mechanisms initiating immunization in hepatocellular carcinoma. In this chapter we have reviewed the hepatobiliary tumors, the role of immunotherapy, and its relevant mechanisms to cancer therapy. In addition, some immunotherapeutic approaches are discussed.

Chapter5.1 - Beneficial and detrimental effects of antioxidants in cancer

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Biology of SARS-CoV-2 Coronavirus; Origin, Structure, and Variants

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Statins: Beneficial Effects in Treatment of COVID-19

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The Relationship Between Psoriasis, COVID-19 Infection and Vaccination During Treatment of Patients

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Virtual Event

Journal Club 1

Phytochemicals as modulators of paraoxonase-1 in health and disease

Journal Club 2

Part1: Systematic review introduction Part2: SIRT1 & Cardiovascular diseases

Journal Club 3

Inhibitors of PI3K/Akt/mTOR pathway in prostate cancer chemoprevention & intervention

Journal Club 4

Tinagl1 suppresses triple-negative breast cancer progression and metastasis by simultaneously inhibiting integrin/FAK and EGFR signaling

Journal Club 5

Ginger and its constituents role in treatment of inflammatory bowel disease

Journal Club 6

Protective effects of curcumin against traumatic brain injury

Journal Club 7

An evaluation of the effect of methylphenidate on working memory, time perception, and choice impulsivity in children with ADHD

Journal Club 8

Dorstarlimab as a miracle drug: rising hope against cancer treatment

Journal Club 9

Variation in Obsessive-Compulsive Disorder Symptoms and Treatments: A Side Effect of Covid-19

Journal Club 10

IDO/Kynurenine: Novel Insight for Treatment of Inflammatory Diseases

Journal Club 11

Designing a Novel mRNA Vaccine Against SARS-COV-2: An Immuno-informatics Approach

Journal Club 12

Novel Pharmacotherapies in Diabetic Retinopathy

Journal Club 13

Impact of Curcumin on p38 MAPK: Therapeutic Implications

Gathering

Gathering 1 (Journal Club)

Phytochemicals as modulators of paraoxonase-1 in health and diseases

Gathering 2 (Journal Club)

SIRT1 and cardiovascular diseases

Gathering 3 (Journal Club)

Inhibitors of the PI3K/Akt/mTOR pathway in prostate cancer chemoprevention and intervention

Gathering 4 (Journal Club)

Tinagl1 suppresses triple-negative breast cancer progression and metastasis by simultaneously inhibiting integrin/FAK and EGFR signaling

Gathering 5 (Journal Club)

Ginger and its constituents role in treatment of inflammatory bowel disease

Gathering 6 (Journal Club)

Protective effects of curcumin against traumatic brain injury

Gathering 7 (Journal Club)

An evaluation of the effect of methylphenidate on working memory, time perception, and choice impulsivity in children with ADHD

Gathering 8 (Journal Club)

Dorstarlimb as a Miracle Drug: Rising Hope Against Cancer Treatment

Gathering 9 (Journal Club)

Variation in Obsessive-Compulsive Disorder Symptoms and Treatments: A Side Effect of Covid-19

Gathering 10 (Journal Club)

IDO/Kynurenine: Novel Insight for Treatment of Inflammatory Diseases

Gathering 11 (Journal Club)

Designing a Novel mRNA Vaccine Against SARS-COV-2: An Immuno-informatics Approach

Gathering 12 (Journal Club)

Novel Pharmacotherapies in Diabetic Retinopathy

Gathering 13 (Journal Club)

Impact of Curcumin on p38 MAPK: Therapeutic Implications