PROFESSIONAL INTERESTS
- Primary Immunodeficiency Diseases
- Natural Killer cells
- The immunological synapse
- Natural Killer cell deficiency
PROFESSIONAL STATEMENT
Jordan S. Orange, M.D., Ph.D., is the chief of Immunology, Allergy, and Rheumatology, professor and section head for Immunology, Allergy and Rheumatology in the department of Pediatrics at Baylor College of Medicine, and the director of the Center for Human Immunobiology at Texas Children’s Hospital. He is a board-certified pediatrician with a clinical specialty in primary immunodeficiency disease. Dr. Orange has focused his research efforts upon Primary Immunodeficiency, NK cell deficiency and the cell biology of human NK cell defenses
After receiving an A.B. in Biology from Brown University, Dr. Orange attended medical school also at Brown University, receiving a Ph.D. in Pathobiology and an M.D. He completed his residency in Pediatrics at the Children’s Hospital of Philadelphia and later a clinical fellowship in Allergy, Immunology and Rheumatology at Boston Children’s Hospital in addition to completing a post-doctoral research fellowship in the Department of Molecular and Cell Biology at Harvard University in Boston.
Dr. Orange has received numerous grants from the likes of the National Institute of Allergy and Infectious Diseases, as well as the United States Immunodeficiency Network. He is also the recipient of several awards including the Judson Daland Prize from the American Philosophical Society for outstanding clinical investigation and was elected to the American Society for Clinical Investigation in 2010.
With his team, Dr. Orange has been instrumental in the use of advanced imaging technology that allowed for crucial insights into these rare immune system diseases, prompting the acquisition of a Leica Microsystems Gated Stimulation Emission Depletion (G-STED) microscope. The G-STED microscope allows researchers to take super-resolution images deep within a living cell.
SELECTED PUBLICATIONS
- "STEPS AND STAGES IN THE FORMATION AND FUNCTION OF THE NK CELL LYTIC IMMUNE SYNAPSE."
- Banerjee PP, Pandey R, Zheng R, Suhoski MM, Monaco-Shawver L, Orange JS. "Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.." J. Exp. Med.. 2007 October 1;204(10):2305-20. Pubmed PMID: 17785506
- Orange JS. "Formation and function of the lytic NK-cell immunological synapse.." Nat. Rev. Immunol.. 2008 September;8(9):713-25. Pubmed PMID: 19172692
- Sanborn KB, Rak GD, Maru SY, Demers K, Difeo A, Martignetti JA, Betts MR, Favier R, Banerjee PP, Orange JS. "Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.." J. Immunol.. 2009 June 1;182(11):6969-84. Pubmed PMID:19454694
- Mentlik AN, Sanborn KB, Holzbaur EL, Orange JS. "Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.." Mol. Biol. Cell. 2010 July 1;21(13):2241-56. Pubmed PMID: 20444980
- Rak GD, Mace EM, Banerjee PP, Svitkina T, Orange JS. "Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse.." PLoS Biol.. 2011 September;9(9):e1001151. Pubmed PMID: 21931536
- James AM, Hsu HT, Dongre P, Uzel G, Mace EM, Banerjee PP, Orange JS. "Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling.." Blood. 2013 April 4;121(14):2627-37. Pubmed PMID: 23380740
- Mace, E.M., Orange, J.S.. "Lytic immune synapse function requires F-actin deconstruction by Coronin 1A." 2014;111:6708-13. Pubmed PMID: 24760828
- "HUMAN NK CELL DEFICIENCIES."
- Orange JS, Roy-Ghanta S, Mace EM, Maru S, Rak GD, Sanborn KB, Fasth A, Saltzman R, Paisley A, Monaco-Shawver L, Banerjee PP, Pandey R. "IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.." J. Clin. Invest.. 2011 April 1;121(4):1535-48. Pubmed PMID: 21383498
- Grier J, Forbes LR, Monaco-Shawver L, Atkinson, T.P. Campbell, KS, Orange JS. "Immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity.." 2012 September 24 Pubmed PMID:23006327
- Orange, J.S.. "Natural killer cell deficiency." 2013;132:515-25. Pubmed PMID: 23993353
- Mizesko MC, Banerjee PP, Monaco-Shawver L, Mace EM, Bernal WE, Sawalle-Belohradsky J, Belohradsky BH, Heinz V, Freeman AF, Sullivan KE, Holland SM, Torgerson TR, Al-Herz W, Chou J, Hanson IC, Albert MH, Geha RS, Renner ED, Orange JS. "Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.." J. Allergy Clin. Immunol.. 2013 March;131(3):840-8. Pubmed PMID: 23380217
- Mace EM, Hsu AP, Monaco-Shawver L, Makedonas G, Rosen JB, Dropulic L, Cohen JI, Frenkel EP, Bagwell JC, Sullivan JL, Biron CA, Spalding C, Zerbe CS, Uzel G, Holland SM, Orange JS. "Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset.." Blood. 2013 April 4;121(14):2669-77. Pubmed PMID: 23365458
- "GENETIC BASIS OF PRIMARY IMMUNODEFICIENCY."
- Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polyc. "A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.."Nature. 2007 August 2;448(7153):591-4. Pubmed PMID: 17632545
- Keller MD, Ganesh J, Heltzer M, Paessler M, Bergqvist AG, Baluarte HJ, Watkins D, Rosenblatt DS, Orange JS. "Severe Combined Immunodeficiency Resulting From Mutations in MTHFD1.." Pediatrics. 2013 February;131(2):e629-34. Pubmed PMID: 23296427
- Stray-Pedersen A, Backe PH, Sorte HS, Morkrid L, Chokshi NY, Erichsen HS, Gambin T, Elgstoen KBP, Bjoras M, Wlodarski M, Kruger M, Jhangiani S, Muzny DM, Patel A, Raymond K, Sasa GS, Krance RA, Martinez CA, Abraham S, Speckmann C, Ehl S, Hall P, Forbes LR. "PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia.." Merkoll E, Westvik J, Nishimura G, Rustad CF. 2014;95:96-107. Pubmed PMID: 24931394
